It collects and stores the substantial amount of data in a stipulated period and helps to take appropriate action as and when required. The proposed architecture is found to be useful in remote and highly congested pandemic areas where either the wireless or Internet connectivity is a major issue or chances of COVID-19 spreading are high. The proposed architecture uses wearable sensors to record the observations in Body Area Networks (BANs) in a push–pull data fetching mechanism. This work investigates the drone-based systems, COVID-19 pandemic situations, and proposes an architecture for handling pandemic situations in different scenarios using real-time and simulation-based scenarios. Drones or Unmanned Aerial Vehicles (UAVs) are very helpful in handling the COVID-19 pandemic. Within eight months (by August 2020), it infected 24.0 million persons worldwide and over 824 thousand have died. It is similar to influenza viruses and raises concerns through alarming levels of spread and severity resulting in an ongoing pandemic worldwide. Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus.